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Immune Response to Influenza

We are currently working on the groundbreaking research on immunity to influenza in humans as a part of NIAID-funded project "Immune Function and Biodefense in Children, Elderly, and Immunocompromised Populations." NIAID has funded ten regional Centers of Excellence for Biodefense and Emerging Infectious Diseases Research. This nationwide network of multidisciplinary academic centers is conducting wide-ranging research on infectious diseases and developing diagnostics, therapeutics, and vaccines. The elderly and immunocompromised patients have altered immune responses to viral and bacterial pathogens are the most susceptible to infection, and at serious risk for serious consequences of infection. We are working on the development of mathematical models for seasonality and generating computer simulations for spatial and temporal aspects of illnesses, which assist researchers to better understand the nature of influenza.

This project is being supported by the National Institute of Allergy and Infectious Diseases (U19AI062627, HHSN266200500032C).

Selected Publications:

Petrova GV, Naumova EN, Gorski J. The Polyclonal CD8 T Cell Response to Influenza M158-66 Generates a Fully Connected Network of Cross-Reactive Clonotypes to Structurally Related Peptides: A Paradigm for Memory Repertoire Coverage of Novel Epitopes or Escape Mutants. J Immunol. 2011 Apr 25. [Epub ahead of print]

Naumov YN, Naumova EN, Yassai MB, Gorski J. Selective T Cell Expansion during Aging of CD8 Memory Repertoires to Influenza Revealed by Modeling. J Immunol. 2011 Apr 22. [Epub ahead of print]

Mor SM, Aminawung JA, Demaria A, Naumova EN. Pneumonia and influenza hospitalization in HIV-positive seniors. Epidemiol Infect. 2010 Nov 26:1-9. [Epub ahead of print]

Lofgren ET, Wenger JB, Fefferman NH, Bina D, Gradus S, Bhattacharyya S, Naumov YN, Gorski J, Naumova EN. Disproportional effects in populations of concern for pandemic influenza: insights from seasonal epidemics in Wisconsin, 1967-2004. Influenza Other Respi Viruses. 2010 Jul;4(4):205-12.

Naumov YN, Naumova EN, Yassai MB, Kota K, Welsh RM, Selin LK. Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus. J Immunol. 2008 Nov 15;181(10):7407-19.